Theses

Available Theses

Several topics appropriate for thesis in medicine are available, dealing with all research themes addressed by BRighTEN scientific activity. For more information, please contact Prof. Matilde Inglese m.inglese@unige.it

2025 Neurology Residency

Vincenzo Daniele Boccia: Predicting disability accrual and cognitive decline in the era of high efficacy disease modifying treatments in Multiple Sclerosis

Abstract: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, leading to progressive motor and cognitive disability. Despite the success of high-efficacy disease-modifying treatments (HETs) in reducing inflammation, disability accrual continues through neurodegenerative mechanisms. This study investigates the predictive value of novel MRI biomarkers, such as brain atrophy and paramagnetic rim lesions (PRLs), in assessing long-term disability progression. Our findings suggest that integrating brain atrophy into the NEDA-4 composite measure improves the prediction of future disability in patients receiving HETs. Additionally, PRLs were identified as significant predictors of cognitive decline, even in relapse-free patients. These results highlight the limitations of traditional biomarkers and emphasize the need for novel neuroimaging tools to guide MS management. The integration of these biomarkers could improve patient stratification and enable a precision medicine approach in MS treatment.

Tommaso Sirito: Beyond the tip of the iceberg in multiple sclerosis: the role of OCT and MRI in disease monitoring

Abstract: Multiple sclerosis (MS) is a complex and heterogeneous disease, with inflammatory and neurodegenerative components contributing to disability accumulation. Given its multifaceted nature, a multiparametric approach is essential to evaluate both the efficacy and speed of action of different disease-modifying therapies (DMTs). This study integrates clinical, radiological, and advanced imaging biomarkers—such as optical coherence tomography (OCT) and diffusion MRI—to assess short-term treatment response and long-term neurodegenerative processes. Our findings highlight how a comprehensive evaluation can provide valuable insights into the mechanisms of action of DMTs, optimizing therapeutic strategies and personalized treatment decisions.

2024 Sara Sulfaro: Predictive radiological parameters of short-term neurodegeneration in multiple sclerosis